Spying on sickness

FISH may soon be used in the search for treatments for human diseases. Developmental biologists have long loved zebrafish (Danio rerio) because their embryos can be observed through their translucent eggs. Now researchers have realised that zebrafish are also ideal for modelling disease (Nature Genetics, vol 20, p 239, 244). By subjecting zebrafish sperm to mutating agents and screening the embryos, scientists have bred fish with conditions similar to anaemia and another blood disease, porphyria. Studying the fish could lead to new ways to treat the conditions. “We’ll find more and more disease models,” says one of the researchers,
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